The Bioenhancer Piperine is at Least Trimorphic

Piperine, a Natural Bioenhancer, Nullifies the Antidiabetic and Antioxidant Activities of Curcumin in Streptozotocin-Diabetic Rats

Knowing that curcumin has low bioavailability when administered orally, and that piperine has bioenhancer activity by inhibition of hepatic and intestinal biotransformation processes, the aim of this study was to investigate the antidiabetic and antioxidant activities of curcumin (90 mg/kg) and piperine (20 or 40 mg/kg), alone or co-administered, incorporated in yoghurt, in streptozotocin (STZ)...

Formulation and Evaluation of Reservoir Type Transdermal Patches of 18-β-glycyrrhetic Acid with Piperine as Bioenhancer

The Exponent of Discrepancy Is at Least 1.0669

Let P 0; 1] d be an n-point set and let w : P ! 0; 1) be a weight function with w(P) = P z2P w(z) = 1. The L 2-discrepancy of the weighted set (P; w) is deened as the L 2-average of D(x) = vol(B x) ? w(P \ B x) over x 2 0; 1] d , where vol(B x) is the volume of the d-dimensional interval B x = Q d k=1 0; x k). The exponent of discrepancy p is deened as the innmum of numbers p such that for all ...

Docking studies of piperine - iron conjugate with human CYP450 3A4

Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprotein substrates. However, there areno evidences on piperine-iron conjugate to inhibit human CYP450 ...

At Least at the Level of Inferior Temporal Cortex, the Stereo Correspondence Problem Is Solved

Stereoscopic vision requires the correspondence problem to be solved, i.e., discarding "false" matches between images of the two eyes, while keeping correct ones. To advance our understanding of the underlying neuronal mechanisms, we compared single neuron responses to correlated and anticorrelated random dot stereograms (RDSs). Inferior temporal neurons, which respond selectively to disparity-...